Comparative analysis of combination kanamycin-furosemide versus kanamycin alone in the mouse cochlea
نویسندگان
چکیده
منابع مشابه
Kanamycin-furosemide ototoxicity in the mouse cochlea: a 3-dimensional analysis.
OBJECTIVE Administration of an aminoglycoside antibiotic and loop diuretic causes damage to hair cells in the organ of Corti, resulting in their death and the death of their corresponding spiral ganglion neurons. While this phenomenon has been studied previously, analysis of its effects in the whole cochlea has not been reported. The authors sought to evaluate the effects of a combination dose ...
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Gentamicin, sisomicin, tobramycin, and kanamycin were compared in parallel tests in vitro and in vivo against a variety of bacterial strains and species. A number of differences were seen in vitro, in particular: (i) the lower activity of kanamycin, (ii) the greater activity of tobramycin against Pseudomonas, (iii) the greater activity of gentamicin and sisomicin against Serratia, and (iv) the ...
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ژورنال
عنوان ژورنال: Hearing Research
سال: 2011
ISSN: 0378-5955
DOI: 10.1016/j.heares.2010.10.011